Abnormal processing of TAR DNA binding protein 43 (TDP-43) has been identified as a major factor in neuronal degeneration during amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD). It is unclear how changes to TDP-43. including nuclear to cytosolic translocation and subsequent accumulation. are controlled in these diseases. https://www.prepobsessedes.shop/product-category/crossbody/
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